Axon regeneration promoter

Details Axon regeneration promoter Axon regeneration promoter

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/4409 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2559069

An axon regeneration promoter which contains an RGM-like protein inhibitor as the active ingredient. Examples of the RGM-like protein inhibitor include anti- RGM-like protein antibodies, RGM-like protein inhibitors such as Y27632 and antisense nucleic acids and double-stranded DNAs capable of inhibiting the transcription or translation of RGM-like proteins. This axon regeneration promoter is efficacious in the regeneration of a central nerve axon and thus contributes to, for example, the treatment of a patient suffering from injury in the central nerve system such as the spinal cord by a traffic accident, cerebrovascular disorder, etc.

Promoteur de régénération d'axones qui contient un inhibiteur de protéines de type RGM en tant qu'ingrédient actif. Des exemples dudit inhibiteur de protéines de type RGM comprennent des anticorps protéiques de type anti-RGM, des inhibiteurs de protéines de type RGM tels que Y27632, des acides nucléiques antisens et des ADN à double brin capables d'inhiber la transcription ou la traduction de protéines de type RGM. Ledit promoteur de régénération d'axones est efficace pour régénérer un axone du système nerveux central et contribue donc, par exemple, au traitement d'un patient souffrant d'une lésion du système nerveux central telle qu'une lésion de la moelle épinière à la suite d'un accident de la circulation, d'un trouble cérébrovasculaire, etc.

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