C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61P 31/18 (2006.01) C07D 215/48 (2006.01) C07D 221/00 (2006.01) C07D 471/00 (2006.01) C07D 471/16 (2006.01) C07D 487/00 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2425440
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
L'invention concerne des dérivés d'aza- et de polyaza-nathtalenyl carboxamides, y compris certains dérivés de quinoline carboxamide et naphtyridine carboxamide. Ces composés sont des inhibiteurs de l'intégrase du VIH et des inhibiteurs de la réplication du VIH, et sont utiles dans la prévention et le traitement d'une infection par le VIH et le traitement du SIDA, comme composés ou sels pharmaceutiquement acceptables ou comme ingrédients dans des compositions pharmaceutiques, éventuellement combinés avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des méthodes destinées à prévenir, traiter ou à retarder l'apparition des premiers signes du SIDA ainsi que des méthodes de prévention ou de traitement d'une infection par le VIH.
Anthony Neville J.
Bennett Jennifer J.
Egbertson Melissa
Embrey Mark
Fisher Thorsten E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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