C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/54 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01) C07D 215/38 (2006.01) C07D 237/30 (2006.01) C07D 417/00 (2006.01) C07D 471/02 (2006.01) C07D 471/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2425395
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
L'invention concerne des dérivés aza et polyazanaphthalénylcarboxamides comprenant certains dérivés quinoline carboxamides et naphthyridine carboxamides, qui constituent des inhibiteurs de la VIH intégrase et des inhibiteurs de la réplication du VIH. Ces composés sont utiles dans la prévention ou le traitement d'une infection par VIH et dans le traitement du SIDA, en tant que tels ou sous la forme de leurs sels pharmaceutiquement acceptables, ou bien en tant qu'ingrédients de compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des procédés permettant de prévenir, de traiter ou de retarder l'apparition du SIDA, ainsi que des procédés permettant de prévenir ou de traiter une infection par VIH.
Anthony Neville J.
Bennett Jennifer J.
Egbertson Melissa S.
Gomez Robert P.
Wai John S.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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