Aza-and polyaza-naphthalenyl carboxamides useful as hiv...

Details Aza-and polyaza-naphthalenyl carboxamides useful as hiv... Aza-and polyaza-naphthalenyl carboxamides useful as hiv...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/53 (2006.01) A61P 31/18 (2006.01) C07D 215/12 (2006.01) C07D 215/16 (2006.01) C07D 215/38 (2006.01) C07D 237/26 (2006.01) C07D 237/28 (2006.01) C07D 239/72 (2006.01) C07D 241/36 (2006.01) C07D 251/00 (2006.01) C07D 257/08 (2006.01) C07D 401/02 (2006.01) C07D 403/00 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2425625

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating, or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

Cette invention concerne des dérivés d'aza- et de polyaza-naphthalényl carboxamide, dont certains dérivés de quinoline carboxamide et de naphthyridine carboxamide, qui sont décrits comme des inhibiteurs de l'intégrase du VIH et comme des inhibiteurs de la réplication du VIH. Ces composés sont utiles pour la prévention ou le traitement de l'infection par le VIH et pour le traitement du SIDA, en tant que tels ou sous forme de sels pharmaceutiquement acceptables, ou comme ingrédients de compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. Sont également décrites des méthodes permettant de prévenir, de traiter ou de retarder l'apparition du SIDA ainsi que des méthodes de prévention ou de traitement de l'infection par le VIH.

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