Aza-and polyaza-naphthalenyl ketones useful as hiv integrase...

Details Aza-and polyaza-naphthalenyl ketones useful as hiv integrase... Aza-and polyaza-naphthalenyl ketones useful as hiv integrase...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 215/04 (2006.01) C07D 215/26 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2425067

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

L'invention concerne certains aza- et polyaza-naphtalényl cétones, dont certains quinolinyl et naphthyridinyl cétones utilisés en tant qu'inhibiteurs de l'intégrase du VIH et en tant qu'inhibiteurs de la réplication du VIH. Ces composés sont utiles dans la prévention ou le traitement de l'infection par le VIH et le traitement du SIDA ou le retardement de son apparition, en tant que composés ou sels pharmaceutiquement acceptables, ou en tant qu'ingrédients dans les compositions pharmaceutiques, éventuellement en combinaison avec d'autres anti-viraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des méthodes de traitement du SIDA ou des méthodes permettant de retarder son apparition, ainsi que des méthodes de prévention ou de traitement d'une infection par le HIV.

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