Aza-anthracyclinone derivatives

Details Aza-anthracyclinone derivatives Aza-anthracyclinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 451/00 (2006.01) A61K 31/46 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/70 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 209/56 (2006.01) C07D 401/06 (2006.01) C07D 471/08 (2006.01) C07D 491/20 (2006.01) C07D 495/20 (2006.01) C07H 15/24 (2006.01) C07H 15/26 (2006.01) C07K 5/04 (2006.01)

Patent

CA 2227984

Compounds of formula (I) wherein X1 and X2 are C=O, C=NH or CH2, X3 is CH2, CO, CHOH, formula (III), formula (IV) wherein n=2 or 3, and C=N(R9) wherein R9 is hydroxy or amino-aryl, and each of R1, R2, R3, R4, R5, R6, R7 and R8 are hydrogen, halogen or an organic residue, are useful in the treatment of amyloidosis. A process for their preparation and pharmaceutical compositions containing them are also described.

La présente invention se rapporte à des composés de formule (1), dans laquelle X1 et X2 représentent C=O, C=NH ou CH2, X3 représente CH2, CO, CHOH, un composé de formule (III), un composé de formule (IV) où n=2 ou 3, et C=N(R9) où R9 représente hydroxy ou amino-aryle, et R1, R2, R3, R4, R5, R6, R7 et R8 représentent chacun hydrogène, halogène ou un résidu organique. Ces composés sont utiles dans le traitement de l'amylose. L'invention décrit également leur procédé de préparation, ainsi que des compositions pharmaceutiques les contenant.

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