Aza-arylpiperazines

Details Aza-arylpiperazines Aza-arylpiperazines

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/495 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 25/06 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/32 (2006.01)

Patent

CA 2472954

The present invention refers to chemical compounds of formula (I): (Formula I); as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R4 have the significance given in claim 1. They can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.

L'invention concerne des composés chimiques, ainsi que des sels pharmaceutiquement acceptables, des solvates et des esters de ceux-ci, représentés par la formule (I), dans laquelle R?1¿ à R?4¿ sont tels que définis dans la revendication 1. Les composés selon l'invention peuvent être utilisés sous forme de préparations pharmaceutiques dans le traitement ou la prévention des troubles du système nerveux central, des lésions du systèmes nerveux central, des troubles cardio-vasculaires, des troubles gastro-intestinaux, du diabète, de l'obésité et de l'apnée du sommeil.

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