C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/4355 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2660546
The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
L'invention concerne des composés aza-benzofuranyle de formule (I) présentant une activité anti-cancéreuse et/ou anti-inflammatoire, et en particulier des composés aza-benzofuranyle inhibant l'activité de la MEK-kinase. L'invention concerne des compositions et des procédés servant à inhiber une croissance cellulaire anormale ou à traiter un trouble hyperprolifératif, ou à traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés de l'invention visant à diagnostiquer ou à traiter des cellules de mammifères in vitro, in situ, et in vivo pour des troubles pathologiques associés.
Bao Liang
Dyke Hazel Joan
Montana John Gary
Price Stephen
Savy Pascal Pierre
Genentech Inc.
Smart & Biggar
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