Aza-benzothiophenyl compounds and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/4743 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2660963

The invention relates to azabenzothiophenyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzothiophenyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

L'invention concerne des composés aza-benzothiophényle de formule (I) présentant une activité anti-cancéreuse et/ou anti-inflammatoire, et en particulier des composés aza-benzothiophényle inhibant l'activité de la MEK-kinase. L'invention concerne des compositions et des procédés servant à inhiber une croissance cellulaire anormale ou à traiter un trouble hyperprolifératif, ou à traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés de l'invention visant à diagnostiquer ou à traiter in vitro, in situ, ou in vivo des cellules de mammifères ou des troubles pathologiques associés.

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