Aza-bicycloalkyl ethers and their use as alpha7-nachr agonist

Details Aza-bicycloalkyl ethers and their use as alpha7-nachr agonist Aza-bicycloalkyl ethers and their use as alpha7-nachr agonist

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01) C07D 209/00 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2495685

The present invention relates to 1-aza-bicycloalkyl derivatives of formula (I), wherein X is CH2 or a single bond; Y is a group of formula (II, III, IV) and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

L'invention concerne des dérivés de 1-aza-bicycloalkyle représentés par la formule (I), dans laquelle X représente CH¿2 ?ou une liaison unique ; Y représente un groupe représenté par la formule (II), (III) ou (IV) et R est tel que défini dans le descriptif. Les composés selon l'invention sont des agonistes du récepteur nicotinique de l'acétylcholine (nAChR) alpha-7. L'invention concerne également des procédés de production des composés selon l'invention, leur utilisation comme produits pharmaceutiques ainsi que des compositions pharmaceutiques contenant lesdits composés.

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