Aza-bicyclohexyl substituted indolyl alkyl amino derivatives...

Details Aza-bicyclohexyl substituted indolyl alkyl amino derivatives... Aza-bicyclohexyl substituted indolyl alkyl amino derivatives...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2716932

This invention comprises the novel compounds of Formula (I), wherein R1, R', R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Cette invention porte sur les nouveaux composés représentés par la formule (I), dans laquelle R1, R2, R3, R4, A et X ont les significations telles que définies dans la description. Ces composés présentent une activité enzymatique d'inhibition de l'histone désacétylase. L'invention porte également sur leur préparation, sur des compositions les contenant et sur leur utilisation comme médicament.

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