Aza compounds

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C - Chemistry, Metallurgy

07

D

167/211, 260/273

C07D 471/04 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 473/00 (2006.01) C07D 487/04 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2024137

Aza compounds Abstract Azabenzimidazole compounds of the formula Image (I), in which one or two of the variables Z1, Z2, Z3 and Z4 are N and the others are C(R), where R is halogen, acyl, carboxyl which, if desired, is esterified or amidated, or 5-tetrazolyl, or R is -Z-R', wherein Z is a bond or is O, S(O)m or NH, R' is hydrogen or an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen, hydroxyl, unsubstituted or substituted amino or carboxyl which, if desired, is esterified or amidated and which hydrocarbon radical, if desired, is interrupted by O or S(O)m and the index m is in each case 0, 1 or 2, R1 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl or is a cycloaliphatic or araliphatic hydrocarbon radical and R2 is the group of the formula Image (Ia), in which alk is a divalent aliphatic hydrocarbon radical, R3 is COOH, SO3H, haloalkanesulfonylamino, PO2H2, PO3H2 or 5-tetrazolyl and either the rings A and B independently of one another are unsubstituted or substituted by halogen, an aliphatic hydrocarbon radical which is unsubstituted or substituted by hydroxyl or halogen and which, if desired, is interrupted by O, hydroxyl which, if desired, is etherified by an a ?natic alcohol, or carboxyl which, if desired, is esterified or amidated or the ring A is substituted by 5-tetrazolyl and the ring B is unsubstituted or substituted as indicated immediately hereinbefore, in free form or in form of a salt, can be manufactured in a manner known per se and can be used, for example, as active ingredients in medicaments.

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