Aza hydroxylated ethyl amine compounds

Details Aza hydroxylated ethyl amine compounds Aza hydroxylated ethyl amine compounds

C - Chemistry, Metallurgy

07

C

C07C 243/28 (2006.01) A61K 31/16 (2006.01) A61P 25/28 (2006.01) C07C 243/32 (2006.01) C07C 311/16 (2006.01) C07C 311/49 (2006.01) C07D 277/56 (2006.01)

Patent

CA 2448084

Disclosed are compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2 and R20 are defined herein. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

L'invention concerne des composés de formule (I) ainsi que des sels pharmaceutiquement acceptables et des esters desdits composés pouvant servir à traiter et/ou prévenir la maladie d'Alzheimer et des maladies analogues. Dans cette formule, R¿N?, R¿C?, R¿1?, R¿2? et R¿20? sont tels que définis dans la description. Parmi ces composés figurent des inhibiteurs de l'enzyme bêta-sécrétase pouvant être employés pour traiter la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt de peptide A bêta chez un mammifère. Les composés selon la présente invention peuvent être utilisés dans des compositions pharmaceutiques ainsi que des méthodes de traitement destinées à réduire la formation de peptide A bêta.

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