Aza-indolyl compounds and methods of use

Details Aza-indolyl compounds and methods of use Aza-indolyl compounds and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/407 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2672327

The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

L'invention concerne des composés azaindolyliques de formule I ayant une activité anticancéreuse et/ou anti-inflammatoire et plus précisément des composés azaindolyliques qui inhibent l'activité de la kinase MEK. L'invention concerne des compositions et des procédés utiles pour inhiber la croissance anormale de cellules ou pour traiter un trouble d'hyperprolifération ou pour traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour le diagnostic in vitro, in situ et in vivo ou le traitement de cellules de mammifères ou d'affections pathologiques associées.

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