Aza-peptides

Details Aza-peptides Aza-peptides

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 31/175 (2006.01) A61K 31/415 (2006.01) A61K 38/04 (2006.01) C07C 281/02 (2006.01) C07C 281/06 (2006.01) C07D 231/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2505150

Provided are peptides comprising at least one azaamino acid and having .beta.- sheet breaking ability, useful in the treatment and prevention of diseases such as alzheimer~s disease, Dementia Pugilistica (including head trauma), Hereditary Cerebral Haemorrhage with amyloidosis of the Dutch type (HCHWA-D) and Vascular Dementia with amyloid angiopathy.

L'invention concerne des peptides comprenant au moins un acide aza-amino et pouvant rompre les feuillets bêta. Ces peptides peuvent servir à traiter et prévenir des maladies telles que la maladie d'Alzheimer, la démence pugiliste (y compris le traumatisme crânien), l'hémorragie cérébrale héréditaire avec amylose de type hollandais (HCHWA-D), ainsi que la démence vasculaire avec angiopathie amyloïde.

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