Aza-quinolinol phosphonate integrase inhibitor compounds

Details Aza-quinolinol phosphonate integrase inhibitor compounds Aza-quinolinol phosphonate integrase inhibitor compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 31/18 (2006.01) C07D 513/04 (2006.01) C07F 9/02 (2006.01)

Patent

CA 2537325

Aza-quinolinol phosphonate compounds and methods for inhibition of HIV- integrase are disclosed. Formula (I). Ar is aryl or heteroaryl connecting R6 to L. L is a bond or a linker connecting a ring atom of Ar to N. The ring atoms, X1-X5 may be N, substituted nitrogen, or substituted carbon, and form rings. The compounds include at least one phosphonate group covalently attached at any site.

L'invention concerne des composés d'aza-quinolinol phosphonate, ainsi que mes méthodes d'inhibition de l'intégrase du VIH. Ar est aryle ou hétéroaryle connectant R?6¿ à L. L est une liaison ou un lieur connectant un atome à noyau Ar à N. Les atomes à noyau X?1¿-X?5¿ peuvent être N, de l'azote substitué, ou du carbone substitué, et forment des noyaux. Lesdits composés contiennent au moins un groupe phosphonate relié par covalence à n'importe quel site.

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