C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/435 (2006.01) A61K 31/438 (2006.01) C07D 451/00 (2006.01) C07D 453/00 (2006.01) C07D 471/20 (2006.01) C07D 491/10 (2006.01) C07D 497/10 (2006.01) C07D 498/10 (2006.01) C07D 513/10 (2006.01)
Patent
CA 2167584
The invention relates to spiro compounds having central and peripheral nervous system activity, for example muscarinic agonist activity, having formulae (I, II, III, IV, V, VI, VII, VIII and IX) and their pharmaceutically acceptable salts, quaternary compounds which are structurally derived from said compounds having a tertiary nitrogen atom, enantiomers and racemates, wherein ring A together with the spiro-carbon atom constitutes a bridged or unbridged ring containing one or two ring nitrogen atoms, and the value of each of the other symbols in the formulae is defined.
Composés présentant une activité au niveau du système nerveux central ou périphérique, par exemple une activité agoniste muscarinique, et répondant aux formules (I, II, III, IV, V, VI, VII, VIII and IX), et leurs sels pharmaceutiquement acceptables, composés quaternaires dérivés structurellement desdits composés et dotés d'un atome d'azote tertiaire, énantiomères et racémates. Dans lesdites formules, le cycle A constitue, conjointement avec l'atome spiro-carbone, un cycle ponté ou non renfermant un ou deux atomes d'azote de cycle, et la valeur de chacun des autres symboles figurant dans les formules est définie.
Barak Dov
Fisher Abraham
Karton Yishal
Marciano Daniele
Meshulam Haim
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Israel Inst Itute For Biological Research State Of Israel Represented By The Prime Minister's Office
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