Aza-substituted spiro derivative

Details Aza-substituted spiro derivative Aza-substituted spiro derivative

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/4355 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 9/02 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/32 (2006.01)

Patent

CA 2629018

Disclosed is a compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. [In the formula, X, Y, Z and W independently represent a methine group or a nitrogen atom, but all X, Y, Z and W are not methine groups at the same time; A represents -O- or the like; B represents -C(O)- or the like; D represents -(CH2)m2-, -O- or the like, and m2 represents 0 or 1; Q represents a methine group or a nitrogen atom; and R represents a group represented by the following formula (II-1): (Wherein R6, R7 and R8 independently represent a lower alkyl group or the like).]

L~invention concerne un composé représenté par la formule (I) ci-dessous ou un de ses sels pharmaceutiquement acceptables. (I) [Dans la formule, X, Y, Z et W représentent indépendamment un groupement méthine ou un atome d'azote, tous les X, Y, Z et W n~étant pas en même temps des groupements méthine ; A représente -O- ou analogue ; B représente -C(O)- ou analogue ; D représente -(CH2)m2-, -O- ou analogue ; et m2 représente 0 ou 1 ; Q représente un groupement méthine ou un atome d~azote ; et R représente un groupement représenté par la formule suivante (II-1) : (II-1) (dans laquelle R6, R7 et R8 représentent indépendamment un groupement alkyle inférieur ou analogue).]

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