C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/06 (2006.01) A61K 31/495 (2006.01) A61K 31/675 (2006.01) C07D 241/38 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2154624
Azaaliphatically bridged quinoxaline-2,3-diones of formula I Image (I), wherein A1 is lower alkylidene or a group of the formula >CH-A4-R4 (Ia), A2 is lower alkylidene or a group of the formula >CH-A4-R4 (Ia) or >C=O (Ib) or >CH(OH)-A5-R4(Ic), A3 is a group of the formula >N-A6-R5 (Id), A4 is lower alkylene, A5 and A6 are each independently of the other lower alkylene or a direct bond, n is 0 or 1, R1 and R2 are each independently of the other hydrogen, lower alkyl- and/or lower alkanoyl-substituted amino, nitro, lower alkanoyl, free or etherified hydroxy, free or esterified carboxy, carbamoyl, cyano, unsubstituted or halogenated lower alkyl or halogen, R3 is hydrogen or hydroxy, R4 is free or esterified or amidated carboxy, free or esterified phosphono or 5-tetrazolyl, and R5 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, lower alkanoyl, free or esterified or amidated carboxy, cyano, 5-tetrazolyl, free or etherified or esterified hydroxy or dihydroxy- lower alkyl, and their salts have antagonistic properties with respect to excitatory amino acids and can be used as anticonvulsive and anti-neurodegenerative medicinal active ingredients.
Moretti Robert
Zimmermann Kasper
Fetherstonhaugh & Co.
Novartis Ag
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