C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/4353 (2006.01) A61K 31/437 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 497/04 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2305370
The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with azabenzimidazole-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to azabenzimidazole compounds and pharmaceutical compositions comprising these compounds.
La présente invention concerne en partie des méthodes de modulation de la fonction de protéines kinases de sérine/thréonine avec des composés à base d'azabenzimidazole. Les méthodes comprennent des cellules exprimant une protéine kinase de sérine/thréonine, telles que RAF. L'invention concerne également des méthodes de prévention et de traitement de troubles liés à la protéine kinase de sérine/thréonine dans des organismes, à l'aide d'un composé identifié grâce à l'invention. En outre, l'invention fait appel à des composés à base d'azabenzimidazole et des compositions pharmaceutiques comprenant ces composés.
App Harald
Kutscher Bernhard
Mcmahon Gerald
Weinberger Heinz
Asta Medica Aktiengesellschaft
Marks & Clerk
Zentaris Gmbh
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