Azabenzodiazepines as phosphodiesterase-4 inhibitors

Details Azabenzodiazepines as phosphodiesterase-4 inhibitors Azabenzodiazepines as phosphodiesterase-4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/16 (2006.01) A61K 31/55 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 243/00 (2006.01)

Patent

CA 2542720

Compounds of formula (I): characterized in that: .bullet. Rl represents a group selected from hydrogen atom, methyl, methoxy, hydroxy, amino, dimethylamino, acetamido, pyrrolidin-l-yl, and hydroxymethyl; .bullet. R2 represent a group selected from phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, indolyl, pyrolyl, [1,2,3]-triazolyl, benzo[c]isoxazolyl, thienyl, pyrazolyl, isothiazolyl, imidazolyl, benzofuranyl, pyrazolo[5,1- c][1,2,4]triazyl each of these groups being optionally substituted from 1 to 3 groups, identical or different independently of each other, selected from halogen, trifluoromethyl, (C1-C4)alkyl, (CI-C4)alkoxy, hydroxy, amino, acetamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acetylmethoxy, cyclopentyloxy; optionally, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as active ingredient in pharmaceutical composition useful for treating diseases involving therapy by inhibition of PDE4.

Composés répondant à la formule (I) et caractérisés en ce que R¿l? représente un groupe choisi parmi un atome d'hydrogène, méthyle, méthoxy, hydroxy, amino, diméthylamino, acétamido, pyrrolidin-l-yle, and hydroxyméthyle; R¿2? représente un groupe choisi parmi phényle, pyridyle, pyrimidyle, quinolyle, isoquinolyle, indolyle, pyrolyle, [1,2,3]-triazolyle, benzo[c]isoxazolyle, thiényle, pyrazolyle, isothiazolyle, imidazolyle, benzofuranyle, pyrazolo[5,1-c][1,2,4]triazyle, chacun de ces groupes étant éventuellement substitué par 1 à 3 groupes identiques ou différents choisis indépendamment les uns des autres parmi halogène, trifluorométhyle, alkyle (C1-C4), alkoxy (C<SB>I</SB>-C4), hydroxy, amino, acétamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acétylméthoxy, cyclopentyloxy; éventuellement leurs isomères optiques, et leurs sels d'addition avec un acide ou une base pharmaceutiquement acceptable ; ainsi que leur utilisation comme ingrédient actif dans une composition pharmaceutique utilisable dans le traitement de maladies impliquant une thérapie par inhibition de PDE4.

Affiliated with

Also associated with

Rating

Azabenzodiazepines as phosphodiesterase-4 inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azabenzodiazepines as phosphodiesterase-4 inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azabenzodiazepines as phosphodiesterase-4 inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1829511