Azabenzoxazoles for the treatment of cns disorders

Details Azabenzoxazoles for the treatment of cns disorders Azabenzoxazoles for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/551 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2587826

The present invention relates to .alpha.7 nicotinic receptor agonists of formula I as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an .alpha.7 nicotinic receptor agonist of formula I as shown herein. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant .alpha.7 nicotinic receptor agonist of formula I.

Cette invention concerne des agonistes du récepteur a7-nicotinique représentés par la formule (I), tels que décrits dans les pièces descriptives de la demande, ainsi qu'un procédé pour traiter les troubles du système nerveux central et d'autres troubles chez un mammifère, notamment l'homme, en administrant à ce mammifère un agoniste du récepteur a7-nicotinique de formule (I). Cette invention concerne également des compositions pharmaceutiques contenant un véhicule pharmaceutiquement acceptable et un agoniste du récepteur a7-nicotinique de formule (I), pénétrant dans le système nerveux central .

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