Azabenzoxazoles for the treatment of cns disorders

Details Azabenzoxazoles for the treatment of cns disorders Azabenzoxazoles for the treatment of cns disorders

C - Chemistry, Metallurgy

07

D

C07D 519/00 (2006.01) A61K 31/551 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2587461

The present invention relates to .alpha.7 nicotinic receptor agonists of formula (I) as described herein and to a method for treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal an .alpha.7 nicotinic receptor agonist of formula (I). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant .alpha.7 nicotinic receptor agonist of formula (I).

La présente invention concerne des agonistes du récepteur de nicotine a7 de formule (I) telle que définie dans l'invention, et un procédé pour traiter des troubles du système nerveux central (Central Nervous System / CNS) et d'autres troubles chez un mammifère, par ex. un être humain, par administration au mammifère d'un agoniste du récepteur de nicotine a7 de formule (I). L'invention a également pour objet des compositions pharmaceutiques contenant un excipient acceptable d'un point de vue pharmaceutique et un agoniste du récepteur de nicotine a7 de formule (I), capable de pénétrer dans le système nerveux central.

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