C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/02 (2006.01) A61K 31/403 (2006.01) A61K 31/407 (2006.01) A61K 31/438 (2006.01) A61K 31/439 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 31/12 (2006.01) A61P 33/06 (2006.01) C07D 209/54 (2006.01) C07D 221/20 (2006.01) C07D 221/22 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2474637
Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes of formula I (N, Y, Z,, R, R1-R5 as defined in the claims) which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which involve disturbances of glutamatergic, serotoninergic, and nicotinic transmission, treating immunomodulatory disorders, and antimalaria, antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virus activity.
L'invention concerne des dérivés azabicycliques, azatricycliques et azaspirocycliques d'aminocyclohexanes de formule (I) (N, Y, Z, R, R¿1?, R¿5?, définis dans les revendications) qui sont actifs de manière systémique comme antagonistes des récepteurs de NMDA, des récepteurs de 5HT¿3? et des récepteurs nicotiniques, ainsi que des compositions pharmaceutiques les contenant, leur procédé de préparation, et un procédé de traitement des troubles du SNC impliquant des anomalies de transmission glutamatergique, sérotoninergique et nicotinique, ainsi que des troubles immunomodulatoires, et de l'activité antimalarienne, antitrypanasomale, anti-virus de Borna, anti-HSV et anti-hépatite C.
Danysz Wojciech
Gold Markus
Henrich Markus
Jirgensons Aigars
Kalvinsh Ivars
Merz Pharma Gmbh & Co. Kgaa
Perley-Robertson Hill & Mcdougall Llp
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