C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/395 (2006.01) A61K 31/407 (2006.01) A61K 31/435 (2006.01) A61K 31/4375 (2006.01) A61K 31/439 (2006.01) A61P 31/00 (2006.01) C07D 455/02 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2262460
Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R1 is vinyl or ethyl; and R2 is a group R3, R4CH2-, or R5R6C=CH-; wherein each of R3 and R4 is an azabicyclic ring system or R5 and R6 together with the carbon atom to which they are attached form an azabicyclic ring system, are useful in the prevention and treatment of microbial infections.
Composés de la formule (3) et sels pharmaceutiquement acceptables et leurs dérivés dans laquelle : R?1¿ représente vinyle ou éthyle; et R?2¿ représente un groupe R?3¿, R?4¿CH¿2?, ou R?5¿R?6¿C=CH-; dans lequel chacun des symboles R?3¿ et R?4¿ représente un système à noyau azabicycle, ou R?5¿ et R?6¿ forment ensemble avec l'atome de carbone auquel ils sont liés un système à noyau azabicycle. Lesdits composés servent dans la prévention et le traitement de certaines infections microbiennes.
Hunt Eric
Naylor Antoinette
Takle Andrew Kenneth
Borden Ladner Gervais Llp
Smithkline Beecham P.l.c.
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