Azabicyclic carboxamide derivatives, preparation thereof and...

Details Azabicyclic carboxamide derivatives, preparation thereof and... Azabicyclic carboxamide derivatives, preparation thereof and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2712629

The invention relates to the compounds of general formula (I) in which X1, X2, X3 and X4 are, independently of one another, a nitrogen atom or a C-R1 group; W is an oxygen or sulphur atom; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; A is a bicyclic heteroaryl of formula (II) where Z1, Z2, Z3 and Z4 are, independently of one another, a carbon atom, a nitrogen atom or a C-R2a group; Z5, Z6 and Z7 are, independently of one another, a nitrogen atom or a C-Rb group; Z8 is a carbon atom; in the form of a base or of an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for preparation thereof and therapeutic use.

L'invention concerne les composés de formule générale (I) dans laquelle X1, X2, X3, et X4 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C-R1; W représente un atome d'oxygène ou de soufre; n est égal à 0, 1, 2 ou 3; Y représente un aryle ou un hétéroaryle éventuellement substitué; A représente un hétéroaryle bicyclique de formule (II) où Z1, Z2, Z3, et Z4 représentent, indépendamment l'un de l'autre, un atome de carbone, un atome d'azote ou un groupe C-R2a; Z5, Z6 et Z7 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C-R b,; Z8 représente un atome de carbone; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvate. Procédé de préparation et application en thérapeutique.

Affiliated with

Also associated with

Rating

Azabicyclic carboxamide derivatives, preparation thereof and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azabicyclic carboxamide derivatives, preparation thereof and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azabicyclic carboxamide derivatives, preparation thereof and... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1881301