C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 15/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07D 207/323 (2006.01) C07D 207/44 (2006.01)
Patent
CA 2712609
The invention relates to the compounds of general formula (I) in which X1, X2, X3 and X4 are, independently of one another, a nitrogen atom or a C-R1 group; Z1, Z2, Z3 and Z4 are, independently of one another, a nitrogen atom or a C-R2 group; Ra and Rb form, together with the carbon atoms which bear them, a five-membered ring, this ring comprising a nitrogen atom and carbon atoms, this ring being partially saturated or unsaturated and being optionally substituted with one or more substituents R3; W is an oxygen or sulphur atom; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; in the form of a base or of an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.
L'invention concerne les composés de formule générale (I)dans laquelle X1, X2, X3, et X4 représentent, indépendamment l'un de l'autre, un atome d'azote ou un groupe C-R1; Z1, Z2, Z3 et Z4 représentent, indépendamment l'un de l'autre, un atome d'azote, ou un groupe C-R2; Ra et Rb forment ensemble avec les atomes de carbone qui les portent un cycle à cinq chaînons, ce cycle comportant un atome d'azote et des atomes de carbone, ce cycle étant partiellement saturé ou insaturé et étant éventuellement substitué par un ou plusieurs substituants R3 ; W représente un atome d'oxygène ou de soufre; n est égal à 0, 1, 2 ou 3; Y représente un aryle ou un hétéroaryle éventuellement substitué; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvate. Procédé de préparation et application en thérapeutique.
Dubois Laurent
Evanno Yannick
Machnik David
Malanda Andre
Robic
Sanofi-Aventis
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