Azabicyclic compounds as 5-ht4 receptor antagonists

Details Azabicyclic compounds as 5-ht4 receptor antagonists Azabicyclic compounds as 5-ht4 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 455/02 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2118798

2118798 9305040 PCTABS00020 Compounds of formula (I), wherein X is (a), (b), wherein L is N or CRc wherein Rc is hydrogen, alkoxy, halo, alkyl or cyano; Q is NR1, CH2, O or S; Ra is hydrogen, halo, alkyl, amino, nitro or alkoxy; Rb is hydrogen, halo, alkyl or alkoxy; R1 is hydrogen, alkyl, alkenyl, aralkyl, alkanoyl, or alkanoylalkyl; R2 is alkoxy; and R3 is hydrogen, chloro or fluoro; R4 is hydrogen, alkyl, amino optionally substituted by alkyl, halo, hydroxy or alkoxy; R5 is hydrogen, halo, alkyl, alkoxy, nitro, amino or alkylthio; R6 is hydrogen, halo, alkyl, alkoxy or amino; n is 0, 1, 2, 3 or 4; p and m are independently 0, 1 or 2; and Rq is hydrogen or alkyl. The compounds of the present invention are 5-HT4 receptor antagonists and it is thus believed may generally be used in the treatment or prophylaxis of gastrointestinal disorders, cardiovascular disorders and CNS disorders.

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