C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2071800
T1106 - 1 - ABSTRACT AZABICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY Compounds of formula (I), and salts and prodrugs thereof: Image (I) wherein Q is the residue of an optionally substituted azabicyclic ring system; X represents oxa or thia; Y represents H or hydroxy; R1 represents phenyl or thienyl, either of which groups may be optionally substituted by halo, trifluoromethyl or C1-3 alkoxy, or C5-7 cycloalkyl; R2 represents benzyl which may be substituted in the benzyl ring by halo, trifluoromethyl or C1-3alkoxy, or C5-7 cycloalkyl; and R3, R4 and R5 independently represent H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, -ORa, SCH3, SOCH3, SO2CH3, -NRaRb, -NRaCORb, -NRaCO2Rb, -CO2Ra or -CONRaRb; and Ra and Rb independently represent H, C1-6 alkyl, phenyl or trifluoromethyl, are tachykinin receptor antagonists. They and compositions thereof are useful in therapy.
Baker Raymond
Swain Christopher J.
Teall Martin R.
Williams Brian J.
Merck Sharp & Dohme Limited
Ogilvy Renault
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