C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) A61K 31/695 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2072676
T1107Y - 1 - ABSTRACT AZABICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY Compounds of formula (I), and salts and prodrugs thereof: Image (I) wherein Q is the residue of an optionally substituted azabicyclic ring system; the dotted line represents an optional double bond; X represents H, -OH, =O or halo; R1 represents H, phenyl or thienyl, which phenyl or thienyl groups may be optionally substituted by halo or trifluoromethyl; R2 represents phenyl, thienyl or benzyl, any of which groups may be optionally substituted by halo or trifluoromethyl; and R3, R4 and R5 independently represent H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, -ORa, SRa, SORa, SO2Ra, -NRaRb, -NRaCORb, -NRaCO2Rb, -CO2Ra or -CONRaRb; and Ra and Rb independently represent H, C1-6 alkyl, phenyl or trifluoromethyl, are tachykinin receptor antagonists. They and compositions thereof are useful in therapy.
Ladduwahetty Tamara
Swain Christopher J.
Merck Sharp & Dohme Limited
Ogilvy Renault
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