Azabicyclic compounds with alfa7 nicotinic acetylcholine...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2475773

The invention provides compounds of Formula I: (1) wherein Azabicyclo is (2) W is a six-membered heterocyclic ring system having 1-2 nitrogen atoms or a 10- membered bicyclic-six-six-fused-ring system having up to two nitrogen atoms within either or both rings, provided that no nitrogen is at a bridge of ten bicyclic-six-six-fused-ring system, and further having 1-2 substituents independently selected from R3. These compounds may be in the form of pharamaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharamaceuticals to treat diseases or conditions in which .alpha.7 is known t be involved.

L'invention concerne des composés correspondant à la formule I: (1) dans laquelle Azabicyclo est (2) W est un système de noyau hétérocyclique à six éléments comprenant 1 à 2 atomes d'hydrogène ou un système à 10 éléments bicycliques à noyaux fusionnés six par six, qui comprend jusqu'à deux atomes d'azote à l'intérieur d'un ou des deux noyaux, à condition qu'un point de dix systèmes de noyaux fusionnés six par six ne contienne pas d'azote, et possédant en outre 1 à 2 substitutifs sélectionnés indépendamment dans R¿3?. Ces composés peuvent avoir la forme de sels ou de compositions pharmaceutiques, se présenter sous la forme énantiomérique pure et sont utiles dans les préparations pharmaceutiques pour traiter les maladies ou états impliquant A7.

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