Azabicyclo[3.2.1]octane triazolyl tropane derivatives as...

C - Chemistry – Metallurgy – 07 – D

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C07D 451/04 (2006.01) A61K 31/4196 (2006.01) A61K 31/46 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2408909

The present invention provides compounds of the formula (I): wherein R1 is C3- 6 cycloalkyl optionally substituted by one or more fluorine atoms, or C1-6 alkyl optionally substituted by one or more fluorine atoms, or C3-6 cycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and R2 is phenyl optionally substituted by one or more fluorine atoms, to pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such compounds.

L'invention concerne des composés représentés par la formule (I), dans laquelle R?1¿ représente cycloalkyle C¿3-6? éventuellement substitué par au moins un atome de fluor, ou alkyle C¿1-6? éventuellement substitué par au moins un atome de fluor, ou cycloalkylméthyle C¿3-6? dont le cycle est éventuellement substitué par au moins un atome de fluor; et R?2¿ représente phényle éventuellement substitué par au moins un atome de fluor. L'invention concerne également des sels et solvates pharmaceutiquement acceptables de ces composés, ainsi que des procédés de préparation de ces composés, des intermédiaires utilisés dans la préparation de ces composés, des compositions contenant ces composés ainsi que leurs utilisations.

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