Azabicyclo amides and esters as 5-ht _receptor antagonists

Details Azabicyclo amides and esters as 5-ht _receptor antagonists Azabicyclo amides and esters as 5-ht _receptor antagonists

C - Chemistry, Metallurgy

07

D

167/231, 260/272

C07D 453/02 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2030077

Novel azabicyclo amides and esters as antagonists at the 5-HT3 receptor and useful as anti-emetic agents. The aza- bicyclo amides and esters have the formulae: Image ---(I) Image ---(II) wherein Ar is an aromatic group such as phenyl, naphthyl, 3-indolyl, 3- indazolyl, 1-methyl-3-indolyl, 2-methoxyphenyl or 2-methoxy-4- amino-5-chlorophenyl; and X is O or NH.

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