Azabicyclo derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/08 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 471/08 (2006.01) C07D 498/08 (2006.01) C07D 513/08 (2006.01)

Patent

CA 2047848

Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: (see formula I) wherein A is a group of formula (a), (b) or (c): (see formula a, b or c) wherein R1 is hydrogen, C1-C10 alkyl, aralkyl or di(C1-C4) alkylamino(C1-C6)alkyl; R2, R3 and R4 may be the same or different and each is hydrogen, amino, halogen, C1-C4 alkoxy or phthalimide; X is O or NH; R is C1-C4 alkyl; and Y is NR, O or S; having 5-HT3 receptor antagonist activity.

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