Azabicyclo derivatives as muscarinic receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/52 (2006.01) A61K 31/403 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2522071

This invention generally relates to muscarinic receptor antagonists of formula(I) which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, as well as pharmaceutical compositions containing such compounds and methods of treating diseases mediated through muscarinic receptors.

L'invention concerne en général des antagonistes du récepteur muscarinique de formule (I) utiles, entre autres, pour le traitement de différentes maladies des systèmes respiratoire, urinaire et gastro-intestinal qui impliquent les récepteurs muscariniques. Plus spécifiquement, l'invention concerne des dérivés de composés azabicyclo, y compris, par exemple, des azabicyclo[3.1.0]hexanes hexasubstitués, ainsi que des compositions qui contiennent ces composés et des méthodes de traitement de maladies qui impliquent les récepteurs muscariniques.

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