Azabicyclo derivatives as muscarinic receptor antagonists

Details Azabicyclo derivatives as muscarinic receptor antagonists Azabicyclo derivatives as muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/403 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4523 (2006.01) C07D 209/52 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2491998

This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.

L'invention concerne globalement des antagonistes des récepteurs muscariniques utilisés, entre autres, pour le traitement de diverses maladies des systèmes respiratoire, urinaire et gastro-intestinal, induites par les récepteurs muscariniques. L'invention concerne plus précisément des dérivés de composés azabicyclo, y compris, par exemple, des azabicyclo[3.1.0] hexanes 6-substitués, et des dérivés 2,4,6-trisubstitués. L'invention concerne également des compositions pharmaceutiques contenant ces composés et des méthodes destinées au traitement de maladies induites par les récepteurs muscariniques.

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