Azabicycloalkane derivatives and therapeutic uses thereof

Details Azabicycloalkane derivatives and therapeutic uses thereof Azabicycloalkane derivatives and therapeutic uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/517 (2006.01) A61K 31/542 (2006.01) A61P 25/00 (2006.01) C07D 401/06 (2006.01) C07D 471/08 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2354606

The present invention is directed to a compound of the formula (I): (see figure I) and pharmaceutically acceptable salts thereof, wherein R1, R2, Y, U, W, k, A, E, V, R4 and R5 are as defined herein, pharmaceutical compositions thereof, and methods of use thereof in the inhibition of serotonin reuptake, the inhibition of the binding of 5-HT2A serotonin receptors and the treatment of diseases, conditions or disorders of the central nervous system. Further, the present invention is also directed to methods for the preparation of compounds of formula (I) and intermediates useful therefor.

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