C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/4748 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2677713
The invention relates to compounds of the general formula (I) in which: R is a hydrogen or halogen atom; or a hydroxyl, (C1C6)alkoxy, (C3-C7)cycloalkyl-O- or (C3-C7)cycloalkyl-(C-1- C3)alkylene-O- group; or a heterocycloalkyl, aryl ou heteroaryl group; wherein said group can optionally be substituted by one or more groups selected from halogen atoms, (C1C6)alkyl, (C3-C7)cycloalkyl, (C3- C7)cycloalkyl-(C1-C3)alkylene, (C1-C6)alkoxy, (C3-C7)cycloalkyl-O-, (C3- C7)cycloalkyl-(C1C3)alkylene-O-, (C1-C6)fluoroalkyl, (C1C6)fluoroalkoxy, nitro, cyano, hydroxyl, amino, (C1C6)alkylamino or di(C1-C6)alkylamino, heterocycloalkyl, aryl, aryl-(C1C6)alkylene, heteroaryl, heteroaryl-(C1- C6)alkylene, aryl-O-, -C(O)-(C1C6)alkyl groups, the heterocycloalkyl group being optionally substituted by -C(O)O(CH3)3; n is 1 or 2; m is 1 or 2; o is 1 or 2; in the state of a base or an addition salt to an acid, as well as in the hydrate or solvate state. The invention also relates to a method for preparing the same and to the application in therapy.
L'invention concerne les composés de formule générale (I) dans laquelle R représente soit un atome d'hydrogène ou d'halogène; soit un groupe hydroxyle, (C1C6)alcoxy, (C3-C7)cycloalkyle-O- ou (C3-C7)cycloalkyle-(C-1- C3)alkylène-O-; soit un groupe hétérocycloalkyle, aryle ou hétéroaryle; ce groupe pouvant éventuellement être substitué par un ou plusieurs groupes choisis parmi les atomes d'halogènes, les groupes (C1C6)alkyle, (C3-C7)cycloalkyle, (C3- C7)cycloalkyle-(C1-C3)alkylène, (C1-C6)alcoxy, (C3-C7)cycloalkyle-O-, (C3- C7)cycloalkyle-(C1C3)alkylène-O-, (C1-C6)fluoroalkyle, (C1C6)fluoroalcoxy, nitro, cyano, hydroxyle, amino, (C1C6)alkylamino ou di(C1-C6)alkylamino, hétérocycloalkyle, aryle, aryle-(C1C6)alkylène, hétéroaryle, hétéroaryle-(C1- C6)alkylène, aryle-O-, -C(O)-(C1C6)alkyle, le groupe hétérocycloalkyle étant éventuellement substitué par -C(O)O(CH3)3; n représente 1 ou 2; m représente 1 ou 2; o représente 1 ou 2; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvat. Procédé de préparation et application en thérapeutique.
Ben Ayad Omar
Leclerc Odile
Lochead Alistair
Saady Mourad
Slowinski Franck
Robic
Sanofi-Aventis
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