Azabicycyclic compounds for relieving pain and treating...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/04 (2006.01) A61K 31/403 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2539811

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas (1 or 2), as described herein. The compounds of Formulas (1 and 2) are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.

Les patients sujets à des troubles ou souffrant de troubles, tels que des troubles du système nerveux central, se caractérisant par une altération de la libération des neurotransmetteurs normale, telle que la libération de la dopamine (parkinsonisme, maladie de Parkinson, syndrome de Tourette, trouble déficitaire de l'attention ou schizophrénie, par exemple), sont traités selon une méthode consistant à leur administrer un composé représenté par les formules générales 1 ou 2. Ces composés représentés par les formules générales 1 et 2 peuvent également être utilisés pour traiter la douleur, la toxicomanie, la dépendance à la nicotine et/ou l'obésité. Ces composés sont disponibles sous forme de stéréo-isomères individuels, de mélanges racémiques, de diastéréomères et analogue.

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