Azacyclic compounds and their preparation and use

Details Azacyclic compounds and their preparation and use Azacyclic compounds and their preparation and use

C - Chemistry, Metallurgy

07

D

167/228, 260/270

C07D 413/04 (2006.01) C07D 211/70 (2006.01) C07D 211/72 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1340943

Novel azacyclic compounds selected from the group consisting of (see formula I), (see formula II) or (see formula III) wherein R1 is H or C1-6-alkyl R3 is ~~ (see formula IV) -CH=N-O-R''' or (see formula V) wherein R' is C3-8-alkyl, cyclopropyl, C4-8-cycloalkyl, benzyl which may be substituted, or C1-4-alkoxy-C1-4-alkyl, and R'' is H or C1-8-alkyl or C1-6-alkoxy or C1-4-alkoxy-C1-4-alkyl or aryl, and R''' is H or C1-6-alkyl or C4-8-cycloalkyl; and R4 is H, C1-8-alkyl or Cl; and (see formula VI) is (see formula VII) or (see formula VIII) provided that R3 is not (see formula IX) or (see formula X), wherein R' is C3-8-alkyl, cyclopropyl or C1-3-alkoxymethyl, and provided that R3 is not -CH=N-OR''', wherein R''' is H or C1-6-alkyl, when the compounds of formula I is (see formula XI) and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.

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