C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/36 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 205/04 (2006.01) C07D 207/12 (2006.01) C07D 211/42 (2006.01) C07D 401/06 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2152925
The present invention relates to compound of formula (I), and salts and prodrugs thereof, wherein n is 1, 2 or 3 and where any carbon atom of (CH2)n may be substituted by R4 and/or R5; X represents O or S; R1 represents optionally substituted (CH2)qphenyl, wherein q is 0, 1, 2 or 3; R2 represents optionally substituted aryl, heteroaryl, benzhydryl or benzyl; R4 and R5 each independently represent H, halo, C1-6alkyl, oxo, CO2Ra or CONRaRb; R6 represents H or C1-6alkyl; R7 represents C1-6alkyl or optionally substituted phenyl; R8 represents H, CORa, CO2Ra, COCONRaRb, COCO2Ra, C1-6alkyl optionally substituted by a variety of substituents or C1-6alkyl, optionally substituted by oxo, substituted by an optionally substituted aromatic heterocycle. The compound are tachykinin antagonists useful for treating pain or inflammation, migraine or emesis.
Baker Raymond
Swain Christopher J.
Williams Brian J.
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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