Azacyclic compounds, processes for their preparation and...

Details Azacyclic compounds, processes for their preparation and... Azacyclic compounds, processes for their preparation and...

C - Chemistry, Metallurgy

07

D

C07D 211/36 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 205/04 (2006.01) C07D 207/12 (2006.01) C07D 211/42 (2006.01) C07D 211/74 (2006.01) C07D 211/76 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 417/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2112397

2112397 9304040 PCTABS00020 Compounds of formula (I), and salts and prodrugs thereof wherein n is 1, 2 or 3; X represents O or S; R1 represents optionally substituted phenyl; R2 represents aryl, heteroaryl, benzhydryl, or benzyl; R4 and R5 each independently represent H, halo, CH2OR9, C1-6alkyl, oxo, CO2R10 or CONR10R11; R8 represents H, COR9, CO2R10 or optionally substituted C1-6alkyl; R9 represents H, C1-6alkyl or phenyl; and R10 and R11 each independently represent H or C1-6alkyl; are tachykinin antagonists. They and compositions thereof are useful in medicine.

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