Azacycloalkane derivatives as inhibitors of...

Details Azacycloalkane derivatives as inhibitors of... Azacycloalkane derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2676199

Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

L'invention concerne des dérivés de azacycloalkane représentés par la formule structurelle I, qui sont des inhibiteurs sélectifs de stearoyl-coenzyme A delta-9 desaturase (SCD1) par rapport à d'autres stearoyl-coenzyme A desaturases connues. Les composés de cette invention conviennent pour la prévention et le traitement d'états associés à la synthèse et au métabolisme des lipides anormaux, notamment de maladies cardio-vasculaires, telles que l'athérosclérose, l'obésité, le diabète, des maladies neurologiques, le syndrome métabolique, la résistance à l'insuline et la stéatose hépatique.

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