Azacycloalkane derivatives as inhibitors of...

Details Azacycloalkane derivatives as inhibitors of... Azacycloalkane derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/454 (2006.01) A61P 3/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2670703

Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

L'invention porte sur des dérivés d'azacycloalkane de la formule structurelle I qui sont des inhibiteurs sélectifs de la coenzyme A delta-9 désaturase- stearoyle (SCD1) par rapport aux autres coenzymes A désaturases-stearoyles connues. Les composés de l'invention sont utilisés pour prévenir et traiter les états liés à une synthèse et un métabolisme anormaux des lipides, y compris la maladie cardiovasculaire, par exemple l'athérosclérose, l'obésité, le diabète, la maladie neurologique, le syndrome métabolique, la résistance à l'insuline et la stéatose hépatique.

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