C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/53 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2664849
Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
L'invention concerne des dérivés d'azacycloalcane de formule structurale (I), lesdits dérivés étant des inhibiteurs sélectifs de la stéaroyl-coenzyme A delta-9 désaturase (SCD1) par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés selon la présente invention sont utiles pour la prévention et le traitement de maladies associées à une synthèse et un métabolisme lipidiques anormaux, notamment les maladies cardiovasculaires, telles que l'athérosclérose ; l'obésité ; le diabète ; les maladies neurologiques ; le syndrome métabolique ; la résistance à l'insuline ; et la stéatose du foie.
Deschenes Denis
Gagnon Marc
Leblanc Yves
Oballa Renata M.
Powell David
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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