Azacyclohexane derivatives as inhibitors of...

Details Azacyclohexane derivatives as inhibitors of... Azacyclohexane derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 3/00 (2006.01) C07D 473/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2628996

Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl- coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Dérivés d'azacyclohexane répondant à la formule de structure I, lesquels sont des inhibiteurs sélectifs de la stéaroyl-coenzyme A delta-9 désaturase (SCD1) par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés de la présente invention sont utiles pour la prévention et le traitement d'affections liées à la synthèse et au métabolisme anormaux des lipides, dont des maladies cardiovasculaires, telles que l'athérosclérose ; l'obésité ; le diabète ; des maladies neurologiques ; des syndromes métaboliques ; la résistance à l'insuline ; et la stéatose hépatique.

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