Azacyclohexane derivatives as inhibitors of...

Details Azacyclohexane derivatives as inhibitors of... Azacyclohexane derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2610196

Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl- coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Les dérivés d'azacyclohexane de formule structurelle I sont des inhibiteurs sélectifs de la stéaroyl-coenzyme A delta-9 désaturase (SCD1) par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés de la présente invention sont utiles pour la prévention et le traitement de pathologies liées à la synthèse et au métabolisme anormaux de lipides, y compris les maladies cardiovasculaires; l'athérosclérose; l'obésité; le diabète; les maladies neurologiques; le syndrome métabolique; la résistance à l'insuline; et la stéatose du foie.

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