C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61P 3/06 (2006.01) C07D 207/12 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2654098
Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.
La présente invention concerne des dérivés de l'azacyclopentane de formule structurale (I), qui sont des inhibiteurs sélectifs de la stéaroyl-coenzyme A delta-9 désaturase (SCD1), par rapport à d'autres stéaroyl-coenzyme A désaturases connues. Les composés de la présente invention sont utiles pour la prévention et le traitement de pathologies liées à la synthèse et au métabolisme anormaux de lipides, y compris les maladies cardiovasculaires; l'athérosclérose; l'obésité; le diabète; les maladies neurologiques; le syndrome métabolique; la résistance à l'insuline; la stéatose du foie; ainsi que la stéatohépatite non alcoolique.
Li Chun Sing
Ramtohul Yeeman K.
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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