Azacytidine analogues and uses thereof

Details Azacytidine analogues and uses thereof Azacytidine analogues and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 19/12 (2006.01) A61K 31/706 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2700267

The present invention is directed toward compounds of Formula (I) as follows.wherein, R is H, R5C(O), R5CH2OC(O), or R5CH2NHC(O); R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are independently OH or H, provided that R2 and R3 are not imultaneously OH; R4 is H5 R5C(O), R5CH2OC(O), or R5CH2NHC(O), provided that R and R4 are not simultaneously H; and R5 has the general formula: CH3-(CH2)n-(CH=CH-CH2)m-CH=CH-(CH2)k-. k is an integer from O to 7; m is an integer from 0 to 2; and n is an integer from 0 to 10, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.

L'invention concerne des composés de formule (I), dans laquelle R représente H, R5C(O), R5CH2OC(O), ou R5CH2NHC(O); R1 représente l'emplacement où la ligne de croisement en pointillé illustre la liaison formée joignant R1 à la molécule de formule (I); R2 et R3 représentent indépendamment OH ou H, pour autant que R2 et R3 ne représentent pas simultanément OH; R4 représente H5 R5C(O), R5CH2OC(O), ou R5CH2NHC(O), pour autant que R et R4 ne représentent pas simultanément H; et R5 de formule générale CH3-(CH2)n-(CH=CH-CH2)m-CH=CH-(CH2)k-. k représente un entier compris entre 0 et 7; m un entier compris entre 0 et 2; et n un entier compris entre 0 et 10, ou un sel pharmaceutique de celui-ci. L'invention concerne enfin des procédés de fabrication et d'utilisation de ces composés.

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