Azacytidine analogues and uses thereof

Details Azacytidine analogues and uses thereof Azacytidine analogues and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 19/12 (2006.01) A61K 31/706 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07H 19/04 (2006.01)

Patent

CA 2700207

The present invention is directed toward compounds of Formula (I); where the crossing dashed line illustrates the bond formed joining R1 to the molecule of Formula (I); R2 and R3 are inde-pendently OH or H, provided that R2 and R3 are not simultaneously OH; R4 is H or R5C(O), provided that R and R4 are not simultane-ously H; and R5 is a C3-C26 alkenyl, or a pharmaceutical salt thereof. Methods of making and using these compounds are also disclosed.

L'invention concerne des composés de formule (I), dans laquelle la ligne de croisement en pointillé illustre la liaison formée joignant R1 à la molécule de formule (I); R2 et R3 représentent indépendamment OH ou H, pour autant que R2 et R3 ne représentent pas simultanément OH; R4 représente H ou R5C(O), pour autant que R et R4 ne représentent pas simultanément H; et R5 représente alcényle en C3-C26, ou un sel pharmaceutique de celui-ci. L'invention concerne enfin des procédés de fabrication et d'utilisation de ces composés.

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